ChIP assay demonstrated that TCF4 binds specifically to the −49 kb region to activate Prox1 expression in intestinal cancer cells (Petrova et al., 2008), whereas in murine hippocampal NSCs, Prox1 activation requires the binding of TCF/LEF to both the −43 and −49 kb regions (Karalay et al., 2011). Here, PROX1 is linked to intestinal cancer.