INS and diabetes mellitus: JAZF1 has been implicated in glucose and lipid homeostasis, insulin signaling, and metabolic disorders such as diabetes (Zeggini et al., 2008; Li et al., 2011; Ming et al., 2014b; Jang et al., 2014; Li et al., 2014; Yuan et al., 2015; Wei et al., 2018; Kobiita et al., 2020; Zhou et al., 2020; Ding et al., 2021; Ding et al., 2022).