Indeed, JAZF1 is found downregulated in pancreatic beta-cells of diabetic patients (Marselli et al., 2010; Taneera et al., 2012; Kobiita et al., 2020), in liver cells of hepatic steatosis patients (Wei et al., 2018) and in metabolic tissues of diabetes and obesity rodent models (Li et al., 2014; Wei et al., 2018; Kobiita et al., 2020; Sághy et al., 2020; Zhou et al., 2020). Here, JAZF1 is linked to diabetes mellitus.