A CRISPR knock-out screen in mouse pancreatic beta cells identified seven NuA4/TIP60 subunits (Tip60, ING3, DMAP1, p400, BRD8, BAF53A and MRGBP) as positive regulators of insulin secretion, involving the complex in beta cell function and arguing for a potential role in diabetes (Fang et al., 2019). This evidence concerns the gene KAT5 and diabetes mellitus.