Particularly, the T2D risk allele rs1635852-T (van Hoek et al., 2008) exhibits cis-regulatory activity over JAZF1 in pancreatic islets, resulting in reduced gene expression (Fogarty et al., 2013; Kobiita et al., 2020), while the rs864745-T allele correlates with lower JAZF1 expression in skeletal muscle (Ding et al., 2022). Here, JAZF1 is linked to type 2 diabetes mellitus.