Finally, Tip60 suppresses the PI3K-Akt pathway in some types of cancer (Yang et al., 2017; Zhang et al., 2018), while Esa1 suppresses the equivalent pathway by acetylating Sip2 (homolog of the mammalian AMPKβ) which promotes its interaction with Snf1 (homolog of the mammalian AMPKα) and inhibition of Snf1-mediated phosphorylation of Sch9 (homolog of Akt) (Lu et al., 2011) (Supplementary Table S1). The gene discussed is KAT5; the disease is cancer.