The significance of LRP4 in nervous system function is further highlighted by its association with several human neurodegenerative diseases, including myasthenia gravis (Kalb et al., 2002; Higuchi et al., 2011; Pevzner et al., 2012; Shen et al., 2013; Tsivgoulis et al., 2014; Chung et al., 2023), amyotrophic lateral sclerosis (ALS) (Tzartos et al., 2014) and Alzheimer’s disease (Choi et al., 2013; Zhang et al., 2020). Here, LRP4 is linked to amyotrophic lateral sclerosis.