However, adult mice with LRP5 deficiency show low bone mass, impaired retinal vascularization, hypercholesterolemia, impaired insulin secretion and impaired mammary development (Kato et al., 2002; Fujino et al., 2003; Lindvall et al., 2006; Ye et al., 2009), phenotypes that are also seen in patients with LRP5 loss-of function-mutations (Baron and Kneissel, 2013). Here, LRP5 is linked to Hypercholesterolemia.