The function of SARM1 in regulating axon degeneration is conserved between humans, mice and zebrafish and the SARM1 locus has been identified in two Genome-wide association studies (GWAS) for Amyotrophic lateral sclerosis (ALS) (Osterloh et al., 2012; Fogh et al., 2014; van Rheenen et al., 2016; Tian et al., 2020; Chen et al., 2021). This evidence concerns the gene SARM1 and amyotrophic lateral sclerosis.