In earlier preclinical studies, FA enabled visualization of a wide range of COX-2-expressing neoplasms, including intestinal polyps in ApcMin mice, 1483 human head and neck squamous cell carcinoma tumor xenografts in nude mice,15 nonmelanoma skin cancer in mice,14 and head-and-neck cancer and colorectal and bladder cancer in dogs.12 The gene discussed is PTGS2; the disease is neoplasm.