Nrf2 regulates the balance of cell redox by facilitating the activity of antioxidant defense components, including heme oxygenase-1 (HO-1), superoxide dismutase (SOD), peroxidase (GSH-Px), and glutathione [15], and dysregulation of Nrf2 is associated with a variety of oxidative stress-related diseases, including neurodegenerative diseases [16], cardiovascular disorders [17], pulmonary diseases [18], and cancer [19]. Here, NFE2L2 is linked to neurodegenerative disease.