In the subsequent ROC curve analysis results, according to the AUC value, we found that ATF4 (AUC = 0.869) had the strongest prognostic ability in asthma patients, followed by FKBP5 (AUC = 0.838), CD44 (AUC = 0.787), SFN (AUC = 0.766), S100A2 (AUC = 0.748), and CYCS (AUC = 0.714). The gene discussed is CYCS; the disease is asthma.