Among them, it is now commonly acknowledged that T lymphocytes’ immune responses, particularly CD8+ T cells, play a crucial role in regulating HBV-induced liver fibrosis (Guidotti et al., 1996; Fisicaro et al., 2020; Tan and Schreiber, 2020; Baudi et al., 2021). Here, CD8A is linked to Hepatic fibrosis.