GCG and type 2 diabetes mellitus: Weight loss of at least 5%–10% is known to reduce complications of T2D and improve quality of life (Apovian et al., 2019), and achieving an HbA1c level below 7% (preferably 6.5%) is indicative of sustained blood glucose regulation; therefore, failure to reach these targets under incretin treatment should define a reasonable threshold beyond which a personalised medicine approach needs to be considered.