After the target genes were predicted by the KEGG classical biopathway database, we found that from the perspective of the correlation between enriched pathway and insulin resistance, some differentially expressed candidate target genes between HC and HS_MS1 groups were markedly enriched in the insulin signaling pathway, insulin resistance, mTOR signaling pathway, type II diabetes mellitus, and MAPK signaling pathway, whilst these candidate target genes between HC and HS_MS2 groups were markedly enriched in the MAPK signaling pathway. Here, INS is linked to Insulin resistance.