LTB4R2 and posterior cortical atrophy: Further studies establishing a strong link between ROS and anoikis resistance show that when PC3 cells are detached, there is an increase in the expression of leukotriene B4 receptor-2 (BLT2), causing a cascade of events- NOX activation, ROS generation, NF-κB activation downstream of BLT2. This BLT2-NOX-ROS-NF-κB axis thus plays a role in incurring anoikis resistance in PCa cells and serves as a novel therapeutic target to overcome resistance (132).