Drug sensitivity analysis showed that Ifosfamide, Amonafide, Chelerythrine and Pyrazoloacridine were positively correlated with mitochondrial gene UQCRB. Chelerythrine, Pyrazoloacridine and other drugs were positively correlated with mitochondrial related gene CMC1. CMC1 and UQCRB mitochondrial related proteins may improve the radiosensitivity of glioma and reduce the ability of drug resistance, providing new hope for the treatment of recurrent glioma patients. This evidence concerns the gene CMC1 and glioma.