Drug sensitivity analysis showed that Ifosfamide, Amonafide, Chelerythrine and Pyrazoloacridine were positively correlated with mitochondrial gene UQCRB. Chelerythrine, Pyrazoloacridine and other drugs were positively correlated with mitochondrial related gene CMC1. CMC1 and UQCRB mitochondrial related proteins may improve the radiosensitivity of glioma and reduce the ability of drug resistance, providing new hope for the treatment of recurrent glioma patients. The gene discussed is UQCRB; the disease is glioma.