A signature was created to assess the prognostic risk score for each glioma patient = (-0.27065 x UQCRB expression) + (0.28075 x CMC1 expression) + (-0.475444 x COX20 expression), and the results are shown in (Figure 3D): HR for UQCRB = 0.763 (0.721-0.807) HR=1.324 (1.213-1.445) for CMC1 and 0.622 (0.477-0.811) for COX20. p<0.001. The gene discussed is COX20; the disease is glioma.