In addition, Tet2 and its new interacting protein Upf1 can participate in the regulation of stress-related mRNA stability in the form of a complex, and the common target genes of Tet2 and Upf1 are mainly involved in axon guidance-related genes, also indicating that neuronal development plays a critical role in chronic stress-related diseases such as depression. The gene discussed is UPF1; the disease is depressive symptom measurement.