However, no robust evidence has been provided to support the correlation between the three common modern lifestyles (smoking initiation, alcohol drinking, and coffee consumption) and reproductive traits (SHBG, bio-T, TT, E2, and AMH) or abnormal menstrual phenotypes (age at menopause, irregular menstrual cycle/bleeding, and dysmenorrhea). The gene discussed is AMH; the disease is Dysmenorrhea.