Fan et al. found that in the cecal ligation and puncture (CLP) septic mice model, down-regulating the expression of myeloid differentiation factor 2 (MD-2), which was the mediator of crosstalk between apoptosis and necroptosis in neurons, could reduce depressive-like behavior in sepsis-associated encephalopathy (Fan et al., 2022). Here, LY96 is linked to Encephalopathy.