Tumor-specific pathways such as MTOR signaling pathway, p53 signaling pathway as well as ERBB signaling pathway were enriched in C1, while others (NOTCH signaling pathway, MAPK signaling pathway, JAK-STAT signaling pathway, TGF-β signaling pathway, WNT signaling pathway and Hedgehog signaling pathway) were enriched in C2. Here, TGFB1 is linked to neoplasm.