CD274 and neoplasm: The tumors can be phenotypically categorized into “hot,” “cold” or “altered” according to the rate of infiltration of CD3+ and CD8+ T-cells at the center of tumor and also alongside its margin (Immunoscore) (Galon and Bruni, 2019), expression of the checkpoint molecules (PD-1 and PD-L1) and tumor mutation burden.