LTF and periodontitis: Wuersching et al. (2021a) demonstrated that LL-37 and human lactoferrin could interfere with the planktonic growth of anaerobic bacteria and the formation of bacterial biofilms, thus reducing the incidence of dental caries and periodontitis. Lactoferrin chimeras have a wide range of antibacterial activities. Ruangcharoen et al. (2017) proved that, compared with minocycline hydrochloride and chlorhexidine digluconate, lactoferrin chimeric could better inhibit the formation of oral multispecies biofilms in vitro, and it could reduce the activity of various bacterial cells in the biofilms.