To address this question, we suggest a combined assessment of different imaging modalities which includes: (i) structural MRI; (ii) task-free functional connectivity but also simple task-engaging fMRI to identify common network-relevant regions that in turn serve as seeds for (iii) fibre tracking on the basis of diffusion tensor imaging and (iv) histopathological surrogate markers for AD, such as amyloid and tau from cerebrospinal fluid or PET. This evidence concerns the gene MAPT and Alzheimer disease.