These observations support the therapeutic roles of NgR(310)ecto-Fc protein to repair denuded axons by enhancing myelin restoration and support the recent findings of the NgR(310)ecto-Fc therapeutic fusion protein in a stroke model.61 Furthermore, the cluster of NogoA+ OPCs localized to demyelinated regions, enriched with ZsGreen+ and myc+ macrophages within the NgR(310)ecto-Fc vector-transduced HSC-transplanted mice, may further support an attractive/mobilization role for NogoA+ OPCs when exposed to local NgR(310)ecto-Fc at lesion sites. Here, RTN4 is linked to stroke disorder.