RTN4R and multiple sclerosis: One of the key pathological hallmarks of multiple sclerosis and EAE is inflammatory cell infiltrates that mobilize to the CNS via extravasating through a leaky BBB.29 We aimed to exploit this biological property of activated immune cells and thereby directly deliver the NgR(310)ecto-Fc protein to the inflammatory demyelinating lesions within the CNS from lineage-differentiated HSCs.