Recent studies on large human cohorts uncovered evidence that the common, sporadic form of Alzheimer’s disease starts with increased Aβ in the brain, which leads to hyper-phosphorylated tau (p-tau) and eventually formation of neurofibrillary tangles (NFTs).3,4 This is in line with several prior findings in humans. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.