It is furthermore very likely that, in Alzheimer’s disease, the reelin-expressing alEC LII-neurons, which project to the hippocampal formation, are the first cortical neurons to die.58,59 Our results allow for an attractive hypothesis that places reelin in the sequence of changes in functional pathways in reelin-expressing alEC LII-neurons resulting in the initiation of Alzheimer’s disease. The gene discussed is RELN; the disease is early-onset autosomal dominant Alzheimer disease.