RELN and early-onset autosomal dominant Alzheimer disease: To determine whether the selective vulnerability of reelin-expressing alEC LII-neurons to accumulate iAβ is linked to their expression of reelin, we experimentally assessed the effects on iAβ levels of lowering the expression of reelin in reelin-expressing alEC LII-neurons of Alzheimer’s disease-rats (hereafter referred to simply as model rats), with the use of a viral vector expressing Re-miRNA (Fig. 1).