For that reason, to confirm FLOT-1/2 as a target antigen in multiple sclerosis and a possible correlation between the absence of IgG oligoclonal bands in CSF and the presence of anti-FLOT-1/2 antibodies, we tested these autoantibodies in a cohort from Hospital de Bellvitge including 49 serum samples from patients fulfilling multiple sclerosis criteria in which oligoclonal bands were not detected. The gene discussed is FLOT1; the disease is multiple sclerosis.