Anoctamin-2 is a calcium-activated chloride-channel protein, also named as transmembrane protein 16B which is predominantly expressed in neuronal and muscle tissue.29 Antibodies against ANO2 in multiple sclerosis patients have been widely studied by Ayoglu et al. 11,30 They used a non-conformational antigen array to discover the presence of anti-ANO2 antibodies in the 15.5% of a 1063 multiple sclerosis patients’ cohort. The gene discussed is ANO2; the disease is multiple sclerosis.