Fasting insulin PRS 3 was also significantly negatively associated with all-cause dementia (HR = 0.94; uncorrected P-value = 4.3e-02) and PRS 7 with Alzheimer’s disease (HR = 0.86; uncorrected P-value = 1.6e-02), although not after Bonferroni correction. This evidence concerns the gene INS and early-onset autosomal dominant Alzheimer disease.