It was found that tau lesion of NFTs in AD brain starts from the trans-entorhinal–entorhinal areas, from there to hippocampus, limbic areas, and finally in the associative and then primary neocortical areas (Braak and Braak, 1991, 1995), which associates strongly with the progression of cognitive impairment (Braak and Braak, 1995). Here, MAPT is linked to Alzheimer disease.