Recently, our group reported on normative data of WT mice (strain C57BL6/129S) and of the triple transgenic mouse model with three mutated human genes associated with familial AD (3 × Tg-AD): Swedish amyloid precursor protein (APPswe); presenilin 1 (PSEN1); microtubule-associated protein tau (MAPT). This evidence concerns the gene PSEN1 and Alzheimer disease.