The 3 × Tg-AD mouse model of familial AD, which harbors three genetic mutations, has been shown to develop age-related, progressive neuropathology, including senile plaques, mainly formed by amyloid beta (Aβ) peptide, and neurofibrillary tangles, mainly composed of hyperphosphorylated tau protein, characteristic of the human familial and sporadic of AD. Here, MAPT is linked to Alzheimer disease.