TGFB1 and neoplasm: Specific proteins such as topoisomerase II (Topo II) inhibitors, TGF-β inhibitors, anti-OLC biomarkers, etc., can be interfered with to prevent the growth, development, and metastasis of tumors and inhibit tumor microcalcification (Makhoul et al., 2016; Scimeca et al., 2020; Simatou et al., 2020).