ANXA2 and breast carcinoma: In addition to the aforementioned studies, Maji et al. (2017) gained insight from the data of proteomic analysis of Exocarta and Jeon that Annexin A2 (AnxA2), a protein associated with processes such as fibrinogen activation, actin-cytoskeleton rearrangement, and cell migration, is abundant in small EVs and that AnxA2 levels were positively correlated with the invasiveness of breast cancer cells.