In addition to the aforementioned studies, Maji et al. (2017) gained insight from the data of proteomic analysis of Exocarta and Jeon that Annexin A2 (AnxA2), a protein associated with processes such as fibrinogen activation, actin-cytoskeleton rearrangement, and cell migration, is abundant in small EVs and that AnxA2 levels were positively correlated with the invasiveness of breast cancer cells. This evidence concerns the gene ANXA2 and breast cancer.