CDCA7, CELSR3, PACS1, SNTB1, and TBC1D31 showed consistent upregulation in CRC tumor samples and pre-surgical cfRNA, while GFI1B, HPGD, SH3BGRL2, SIAE, PKHD1L1, and TDP2 showed downregulation in CRC tumor samples and pre-surgical cfRNA. The gene discussed is TDP2; the disease is neoplasm.