Patients with osteosarcoma who had high SERPINH1-related scores had significantly lower drug sensitivity to AMG-319 2045, AZD3759 1915, AZD8186 1918, Cisplatin 1005, CZC24832 1615, Dactinomycin 1811, Dactolisib 1057, Entospletinib 1630, Foretinib 2040, GSK343 (Figure 10). The gene discussed is SERPINH1; the disease is osteosarcoma.