For example, we have long studied S100A8/A9, a heterodimer complex of the S100-family proteins S100A8 and S100A9; S100A8/A9 is a pioneer secretory factor for the metastatic progression of cancer cells through the mastery of not only cancer cells themselves but also the cancer microenvironment (1–4). The gene discussed is IGKV1D-22; the disease is cancer.