We were able to verify the binding that activates the MCAM signal pathway, that is, the tumor progression locus 2 (TPL2)-ETS variant transcription factor 4 (ETV4)-zinc finger E-box binding homeobox 1 (ZEB1) axis, resulting in the epithelial-mesenchymal-transition (EMT) and subsequent disseminative invasion and the lung tropic metastasis. Here, ZEB1 is linked to neoplasm.