In light of the facts that ELISA detects the intact exosomal-annexin A2 in the sera of the TNBC-bearing patients (36), and anti-annexin A2 antibody inhibits angiogenesis in mouse breast cancer-derived tumor in vivo (37), it may be reasonable to consider that the cancer cell surface annexin A2 fixed by the help of LOXL4 also resides on the exosomal surface even after the secretion as exosome and it acts to make grow angiogenesis. The gene discussed is ANXA2; the disease is breast cancer.