The pathological significance of the extracellular remodeling regulated by LOXes via their enzymatic activities in cancer progression has been described before (9), and in the present study, we thus attempted to determine the autocrine potential of LOXL4 in cancer cells, since another LOX family member acts directly on the cell surface and activates the sensitized cells without extracellular matrices (10). Here, LOXL4 is linked to cancer.