Besides the active working of the LOXL4-mediated abundant COL1A1 as a suitable scaffold for the cell migration and growth of the cancer-associated endothelial cells as well as those of cancer cells, the cancer cell surface annexin A2 force-locked by LOXL4 may be involved in the enhanced angiogenesis event (Figures 2C, D). This evidence concerns the gene ANXA2 and cancer.