Owing to the firm involvement of LOX family proteins in fashioning cancer preferential milieu via remodeling of extracellular matrices via collagen cross-linking, which gives rise to a plethora of stable collagen (18), and thereby facilitating cancer-associated angiogenesis (19), the status of collagen presence and angiogenesis was studied in the resected tumors as imaged in the lower panels of Figures 2A, B. This evidence concerns the gene LOX and cancer.