Conceivably, functional dimensions of LOXL4 such as secretion, catalysis, and the binding to annexin A2 will vary in accord with the splicing event of LOXL4, which may reflect our observation that the genetic ablation of intrinsic LOXL4 or mutant LOXL4 losing catalytic activity stalls the outgrowth of breast cancer. The gene discussed is ANXA2; the disease is breast cancer.