Current investigation shows that the long noncoding RNA HOTAIRM1 facilitated GBM proliferation and invasion by interacting with DNA methyltransferases (Dnmts) EZH2 and G9a and sequestering them away from the HOXA1 gene’s transcription start sites (TSS), therefore promoting the HOXA1 oncogene expression (61). Here, EHMT2 is linked to glioblastoma.