Additionally, the investigators demonstrated the enrichment of low epimutation rates in gene promoters for binding motifs of transcription factors with established roles in CLL progression (NFKB1 and MYBL1), and enhancers in proximity to genes implicated in lymphoproliferation (NOTCH1, NFATC1, and FOXC1) and key CLL signaling pathways (e.g, Wnt and MAPK) (87). This evidence concerns the gene NFATC1 and B-cell chronic lymphocytic leukemia.