AFP and neoplasm: Multivariate analysis demonstrated that tumor diameter >5 cm (HR=1.952, 95% CI=1.182–3.222, P=0.009), microvascular invasion (HR=1.787, 95% CI=1.085–2.944, P=0.023), preoperative high-level SP70 (HR=1.927, 95% CI=1.177–3.156, P=0.009) and high-level AFP (HR=1.766, 95% CI=1.043–2.991, P=0.034) were independent prognostic factors of RFS.