Among the proteins with increased expression in the EO2peak‐severe group were proteins involved in inflammatory and fibrotic processes, including tumor necrosis factor (TNF) receptor superfamily 4 (TNFRSF4), transforming growth factor beta receptor 2 (TGFBR2), TNF superfamily‐11 (TNFSF11), TNF‐beta, CC motif chemokine ligand 27 (CCL27), and IL‐12 A/B, as well as angiopoietin‐2 (ANGPT2) is known to be associated with endothelial dysfunction and was previously associated with severe acute COVID‐19.5 This evidence concerns the gene TNF and endothelial dysfunction.