Interestingly, the imbalance of oxidative stress-related pathways was also exhibited in glioma tissues, and the expression of SYT1, CREB3L3, ITPR1, RASGRF1, RASGRF2, and PDX1 were significantly different from that of para-cancerous tissues (Figure 17A). The gene discussed is CREB3L3; the disease is central nervous system cancer.