We conducted the multivariate logistic regression analysis by including WBC, CRP, basal ganglia infarction, RDW, NIHSS1 score, NIHSS2 score, mRS score, and BI score as independent variables, confirming that the NIHSS1 score (OR: 1.404; 95% CI: 1.205–1.635, p < 0.001), NIHSS2 score (OR: 1.237; 95% CI: 1.041–1.471, p = 0.016), RDW (OR: 2.832; 95% CI: 1.748–4.587; p < 0.001) could independently predict depression at 3 months after ICH (Table 4). This evidence concerns the gene CRP and depressive symptom measurement.