In the logistic regression model that adjusted for the confounders of age, sex, education years, marital status, vascular risk factors, BGLs, baseline NIHSS score, BI score, mRS score, and laboratory data (WBC and CRP), the highest tertile of RDW could independently predict the prevalence of post-ICH depression (model 1b: OR = 5.336, 95% CI = 2.624–10.852, p < 0.001; model 2c: OR = 5.086, 95% CI = 2.482–10.426, p < 0.001; model 3d: OR = 4.225, 95% CI = 1.686–10.586, p = 0.002). This evidence concerns the gene CRP and depressive symptom measurement.