By intersecting DEGs in the PPI clusters and WGCNA module genes, we obtained four hub-shared genes in IS and COVID-19, including PDE5A, ITGB3, CEACAM8, and BPI. PDE5A is a cGMP-specific phosphodiesterase that plays a key role in regulating smooth muscle relaxation in the cardiovascular system (34). The gene discussed is PDE5A; the disease is COVID-19.