It is interesting to note that amongst the Kuwaiti T1DM patients who carried the high-risk HLA-DR genotypes (DR3/DRB5, DR3/DR4, DR3/DR7, DR4/DR4), the “C” allele (in homozygous and heterozygous CT combinations) is detected in majority of the patients (Figure 4). Here, TNFRSF25 is linked to type 1 diabetes mellitus.