This study also report a significant co-inheritance of the CC genotype of IL4 gene polymorphism (−590C/T, rs2243250), and the (AA/Q) genotype of IL13 p.(Arg130Glu) gene polymorphism with the high-risk HLA-DQ and DR genotypes and highlights their significant role in genetic susceptibility of the T1DM in Kuwaiti Arab children. This evidence concerns the gene IL13 and type 1 diabetes mellitus.