CCL5 and thanatophoric dysplasia: Among the major DECs, CCL5 that ranked in top 3 in all 3 groups of TD patients (Supplementary Table S2) and the two related growth factors, PDGF-AA and PDGF-AB/BB, were selected for further ELISA analysis which confirmed that both CCL5 and PDGF-AA were significantly increased in all 3 groups of TD patients (p < 0.02), and PDGF-BB was significantly augmented in TS and PTD patients (p < 0.05) but not in CTD patients (Figure 3).