APP and amyloidosis: In addition, we observed that these cells are preferentially located around the plaques, and the number (Figure 3B) and area (Figure 3C) covered by Iba-1 positive cells surrounding the β-amyloid plaques were increased in APP/PS1 + RE mice, but not in the transgenic sedentary animals, corroborating another study showing that microglia around the amyloid plaques can protect the surrounding environment by forming a barrier of processes that condense the plaques (Condello et al., 2015).