GRIN2A and developmental and epileptic encephalopathy: Only recently, two mutant mouse models with gain-of-function variants on the GluN2A subunit, which is frequently associated with epilepsy in humans (XiangWei et al., 2018), showed an epileptic phenotype and other symptoms similar to the ones described in DEE patients carrying analogous mutations, becoming, therefore, valuable mouse models for GRIN-related DEE (Amador et al., 2020; Bertocchi et al., 2021).