Despite this, rodents with spontaneous seizures can still prove to be excellent preclinical tools such as, for example, mutant mice in which the Tsc1 gene was deleted in Emx1-expressing embryonic telencephalic neural stem cells (NSCs), which recapitulate Tuberous Sclerosis Complex (TSC) neuropathological lesions and present spontaneous generalized cortical seizures in 100% of the mutants by postnatal day (PND) 13 (Magri et al., 2011). This evidence concerns the gene TSC1 and tuberous sclerosis.