Interestingly, BG structural changes have been observed in ALS patients with C9orf72 repeat expansions, where they are associated with cognitive and or behavioral impairment, as well as in presymptomatic C9orf72 carriers when compared to non-carriers (Bede et al., 2013; Walhout et al., 2015; Westeneng et al., 2016; De Vocht et al., 2020; Spinelli et al., 2021). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.