Alternatively, the presence of other neuropathological processes, such as fused in sarcoma (FUS) protein alterations, may occur in BG in initial ALS; this hypothesis is supported by the evidence that initial FTLD cases with a FUS pathology have shown caudate atrophy in comparison with controls (Rohrer et al., 2011). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.