LDLR and obesity due to melanocortin 4 receptor deficiency: In C57BL/6 with knocked low-density lipoprotein, receptor (LDLR-/-) mice fed HFD to induce obesity when given 1 and 3% C. olitorius for 8 weeks showed a significant decrease in body 26.7 and 27.2 g, respectively, when compared to control 28.3 g, p = 0.032 (28).