Accordingly, FACS-sorted, naïve CD62L+CD25-CD44-CD4+ T cells from transgenic allergy mice were co-incubated with syngeneic BMDC in the presence of cognate Art v 1 protein in the presence or absence of BX-795 with and without IL-2 and/or TGF-β1 neutralizing antibodies for 5 days. This evidence concerns the gene CD4 and allergic disease.