GATA3 and allergic disease: In fact, BX-795-dependent inhibition of type 2 cytokine secretion was a robust trait observed in different species and model systems in vitro and in vivo applying, among others, double transgenic allergy mice (Figures 6, 7) and wild type C57BL/6 mice for detailed preclinical analyses (Figure S16), which was accompanied by a decrease in GATA-3 expression in lung T cells of allergen-sensitized and challenged mice (Figures 6; S16).