A single-cell sequencing analyzing T cell composition in NSCLC suggested that patients enriched with “pre-exhausted” CD8+ T cells (CD8-C4-GZMK), non-activated Tregs, and activated CD4+ cells had a much better prognosis than that in patients enriched with exhausted T cells (CD8-C6-LAYN and CD4-C7-CXCL13) and activated Tregs (109). Here, CD8A is linked to non-small cell lung carcinoma.