Likewise, pyroptosis-predominant uncoupling is also tailored to specific conditions where an inflammasome without an ASC focus is achieved under experimental conditions (e.g., NLRC4-caspase-1 complex in ASC-/- macrophages), mutations (e.g., ASCY59A and ASCE80R in NLRP3/AIM2/PYRIN signaling), and infections, and is also dependent on cell type (neutrophils are an exception with smaller ASC specks for p46 and p33/p10 species accumulation but with poor pyroptotic modalities and dynamics, as mentioned previously). The gene discussed is NLRC4; the disease is infection.