ASC speck formation have been observed in immune cells such as monocytes in patients with HIV (205, 206), tuberculosis-immune reconstitution inflammatory syndrome (207), severe COVID-19 (208–211), and primary progressive multiple sclerosis (212), neutrophils in patients with sepsis (213), severe COVID-19 (214), and PAMI syndrome (215), CD1c+ DCs found in human fibrotic kidney tissue (216), and fibroblasts and CD11c+ DCs that are associated with experimental influenza (217). Here, ITGAX is linked to COVID-19.