Studies have shown that CD147 co-localizes with integrin α3β1 and α6β1 in hepatocellular carcinoma cells and mediates FAK-paxillin as well as FAK-PI3K-Ca2+ signaling pathways through their interaction to promote both invasive and metastatic potential of HCC cells (75, 78). This evidence concerns the gene PTK2 and hepatocellular carcinoma.