This is in agreement with another study reporting downregulation of Perforin and IFN-γ on tumor infiltrating lymphocytes, showing signs of disturbed effector function, and expression of molecules associated with lymphocyte exhaustion, such as the programmed cell-death-1 (PD-1) receptor and its ligand, PD-L1 (47–49). The gene discussed is PRF1; the disease is neoplasm.