EHMT2 and neoplasm: Regarding T cells, increased tumor CD8+ T cell infiltration has been shown in several cancer models, such as breast (96, 103), ovary (87, 104), pancreatic (105) and bladder (95) tumor-bearing mice treated with DNMTi, HDACi, EZH2i, G9a/DNMTi and LSD1i, enhancing anti-tumor immunity.