MICA and posterior cortical atrophy: Treatment of PCa cells with the class I histone deacetylase inhibitor (HDACi) valproic acid (VPA), alone or in combination with the DNMT inhibitor hydralazine, was able to upregulate MICA/B and ULBPs expression at the transcriptional level (122, 123) due to dimethylation of histone 3 at lysine 4 (H3K4me2) activating mark increase, as confirmed by chromatin immunoprecipitation (ChIP).