BET small molecule inhibitors, such as the triazolo-benzodiazepine-based JQ1 and the quinolone-based I-BET151, were able to upregulate MICA expression on multiple myeloma cells, due to downregulation of the target gene IRF4, a transcriptional repressor of MICA, increasing their recognition by NK cells (139). The gene discussed is MICA; the disease is plasma cell myeloma.