IFNG and Sepsis: Sepsis caused by Methicillin-resistant Staphylococcus aureus (MRSA) infection was associated with elevated levels of autophagic protein and elevated serum levels of interferon-gamma (IFN-γ) and interleukin (IL)-17; in addition, rapamycin enhanced autophagy to reduce the ratio of Th1 and Th17 cells and promote survival in septic mice (49).