In recent years, the inflammatory response and necroptosis induced by RIPK1 have been extensively studied and are involved in the pathogenesis of various autoimmune and chronic inflammatory diseases, such as neurodegeneration, ischemia-reperfusion injury, severe infections, cardiovascular disease, chronic obstructive pulmonary disease, skin inflammation, systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and psoriasis (13–22). The gene discussed is RIPK1; the disease is inflammatory bowel disease.